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This estrogen loss is especially observed when women approach peri- and postmenopause [9] and has a profound impact on dermal health and affects almost all organ systems, which has an overall negative influence on womens quality of life (QOL) [10]

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This previously unknown RAGRagulator site partially overlaps the mSIN subunit of mTORC2, consistent with the absence of interaction between RAGRagulator and mTORC2 (Extended Data Fig

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