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Tetraterpenes, also called carotenoids, are widespread in higher plants, fungi, algae, and animals and are one of the most potent natural antioxidants [141]

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3.2.3 FUNDC1 mediated mitophagy The FUN14 domain-containing protein 1 (FUNDC1) is widely present on the mitochondrial outer membrane and acts as a regulator of mitochondrial autophagy in response to hypoxia, inducing Parkin-independent mitophagy (Liu et al., 2012)

thus, an advanced level of disability was present before therapy could be applied (Figure 19)