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It is important to understand that while improving gut barrier function is increasingly used in the clinical setting as a therapeutic goal, the evidence is not yet there to support the efficacy of a single intervention in curing a disease by restoring or improving barrier function

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A.AimoneJ

Importantly, the observed attenuation of incremental benefit at higher doses for both agents suggests diminishing returns with dose escalation, reinforcing the need to balance expected benefit against treatment burden and patient-specific factors