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Nettleton JA, Greany KA, Thomas W, Wangen KE, Adlercreutz H, Kurzer MS

Direct provision of TMAO into diet has been shown to increase the development of atherosclerosis in animal models, confirming its pro-atherogenic properties 47 , and multiple clinical studies have confirmed that an elevated TMAO level is associated with increased risks for incident major adverse CV events 48

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Participants with normal hepatic function were eligible for inclusion if they were judged to be of general good health by the investigator, based on a medical examination (including physical examination, medical history, vital signs and ECG) and had liver enzyme levels within prespecified limits (alanine aminotransferase upper limit of normal [ULN] + 10%, aspartate aminotransferase ULN + 20% and total bilirubin ULN + 20%)