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GLP-1 medications can cause fatigue through several mechanisms including reduced caloric intake due to appetite suppression, gastrointestinal side effects leading to dehydration and electrolyte imbalances, and metabolic adjustment to improved blood glucose control
& Gopalakrishnakone, P
(2) It is engineered to favor growth hormone release rather than opioid activity, apparently by targeting ghrelin (growth hormone secretagogue) receptors instead of classical opioid receptors
Nonetheless, any persistent or concerning symptoms should be discussed with your GP or diabetes specialist nurse to ensure appropriate assessment and reassurance
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