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Estrogen disruptors, also known as endocrine-disrupting chemicals (EDCs), can cause estrogen levels to rise in several ways

To do this, these activators enhance beta cell insulin secretion and liver glucose uptake (Matschinsky et al

These include reducing the risk of heart attack and stroke, slowing the decline of kidney function, and reducing the accumulation of damaging fat tissue in the liver

An RCT in obese patients found that GLP-1 receptor activation by the agonist exenatide reduced brain responses on functional MRI to food cues in appetite- and reward-related brain areas including the insula and amygdala, correlating with reductions in food intake [18]