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Blood flow to the kidneys can be reduced by hemorrhage, dehydration, heart failure, pulmonary embolism, sepsis (a systemic inflammatory response caused by infection of the blood), excessive blood calcium, and some drugs, such as nonsteroidal anti-inflammatory drugs (NSAIDs) (Ferri 2014a)

People deficient in POMC also have pale skin and red or light colored hair due to the lack of signaling of pigment-inducing melanocortin 1 receptors in the skin (29)

10.1074/jbc.C400325200 J