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The next day dTAG-v1 (500 nM final concentration) or DMSO (solvent) were added and cells were cultured for another 72 h

Encouraging Aligned Enrollment 5.2

Recent success in the use of proteasome inhibitors in the treatment of hematological malignancies validates the UPS as a viable therapeutic pathway, and substantial effort is now focused on the development of both second-generation proteasome inhibitors as well as novel strategies for the inhibition of upstream UPS enzymes