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The dose-heartburn relationship: what happens when you escalate The SURMOUNT-1 trial data shows a clear dose-response relationship: 2.5 mg (starting dose): 5.1% heartburn rate 5 mg: 7.8% heartburn rate 7.5 mg: 8.9% heartburn rate 10 mg: 9.1% heartburn rate 15 mg (maximum dose): 10.7% heartburn rate The increase from starting dose to maximum dose roughly doubles the incidence

The relationship is likely multifactorialinvolving dose escalation speed, individual brain chemistry, concurrent medications, and nutritional status

Chronic aspartame intake causes changes in the trans-sulphuration pathway, glutathione depletion and liver damage in mice

These medications work by slowing down the digestive process, reducing appetite, and promoting a feeling of fullness