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As with any dietary supplement, those who are pregnant, nursing, taking medications, or managing a medical condition should consult a healthcare professional before use

Indomethacin, a potent inhibitor of 3a-hydroxysteroid dehydrogenase, a key enzyme responsible for the synthesis of allopregnanolone (ALLO) and tetradehydrodeoxycorticosterone (THDOC) (potent selective positive allosteric modulators of the GABA A receptors), has been shown to attenuate brain production of ALLO and THDOC and to improve activity in animals with CLF and mild HE [101]

Ornithine has an anti-fatigue effect by increasing the efficiency of energy consumption and promoting the excretion of ammonia

Physical activity and alpha-lipoic acid modulate inflammatory response through changes in thiol redox status