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Statistical Methods for Study-Level Analyses The PIONEER programme employed the use of two estimands [15]

Tirzepatide targets both the GIP (Glucose-dependent insulinotropic polypeptide) and GLP-1 receptors, enhancing insulin secretion and reduces glucagon secretion in a glucose-dependent manner, contributing to improved glycemic control

Characterized by emotional disturbances, stress, guilt, and treatment avoidance, DD affected approximately 45% of patients worldwide-a prevalence underscoring its clinical significance [Reference Parsa, Aghamohammadi and Abazari57]

Zhao, G., He, F., Wu, C., Li, P., Li, N., Deng, J., Zhu, G., Ren, W