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The GLP-1 receptor is not overstimulated, which can cause severe GI distress ### What Happens in Your Body After a Missed Dose Here is a timeline of what occurs when you miss your scheduled weekly injection: **Hours 024 after missed dose:** - Drug levels are still near peak from the previous week's injection - Most patients notice no difference - Appetite suppression still fully active **Hours 2472 after missed dose:** - Drug levels begin to noticeably decline - Some patients report subtle increase in appetite or food cravings - Blood sugar control (for diabetic patients) may start to waver slightly **Days 37 after missed dose:** - Drug levels drop below therapeutic threshold for some patients - Appetite may return noticeably - Food noise (intrusive thoughts about food) may increase - Blood sugar fluctuations become more likely for diabetic patients **Days 714 without dosing:** - Most of the previous dose has been eliminated - Appetite suppression is significantly reduced - Weight loss progress stalls - Risk of compensatory overeating increases **Beyond 2 weeks without dosing:** - Drug levels are minimal - Full appetite returns for most patients - May need to restart at a lower dose to avoid side effects upon resumption ## Detailed Missed Dose Scenarios ### Scenario 1: You Forgot and It's the Same Day **Example**: Your injection day is Friday

We're seeing incredible weight loss (mean reduction of 28.7% at the 12 mg dose) alongside a substantial ~76% improvement in WOMAC pain scores