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In June, citing the severe and irreversible nature of NAION and the growing popularity of GLP-1 RAs, along with safety questions over the past year, the FDA launched a Sentinel study to evaluate the potential increased risk for sudden blindness, while using medications like Ozempic, Rybelsus and Wegovy

A comprehensive review of 118 trials found clinically meaningful benefits, and the Cochrane Review of 50 trials with nearly 8,000 participants confirmed that naltrexone reduces the risk of heavy drinking

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Even so, the extract still changed how genes linked to mitochondrial function responded , pointing to other mechanisms that were not directly measured