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These pseudopeptides that have been studied in some detail are encompassing -amino acid residues and 12 , in addition a conformationally constrained residue close to the C-terminal of the peptide

MOTS-c activates AMPK (AMP-activated protein kinase), the master metabolic switch that signals cells to increase glucose uptake, accelerate fat oxidation, and promote mitochondrial biogenesis

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It reduces TNF-alpha production along with IL-1beta, IL-6, IL-8, and other cytokines at the transcriptional level