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Moreover, by its competitive inhibition of phosphodiesterase, leading to an elevation of myocardial cyclic adenosine monophosphate, caffeine exerts a positive inotropic action on myocardium (Kaur et al., 2022)

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NNMT is an enzyme that catalyzes the methylation of nicotinamide (a NAD+ precursor) and other substrates, using SAM (S-adenosylmethionine) as the methyl donor