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Hepatic Steatosis : Recently, a sub-study of the phase 3 clinical trial SURPASS-3 showed that, among patients receiving metformin and/or SGLT2 inhibitors, the addition of tirzepatide (10 or 15 mg) as compared to insulin degludec was able to significantly reduce hepatic fat content (evaluated by magnetic resonance) after 52 weeks of treatment

Whether more frequent or less frequent administration would be more effective remains unknown

Supports cardiovascular health by improving blood flow and heart function May improve cognitive function and brain health Supports muscle recovery and reduces muscle fatigue Helps regulate blood sugar levels Can boost immune system function

These findings indicate that GLP-1RAs limit and stabilize the development of atherosclerotic plaques through anti-inflammatory mechanisms and by preventing vascular remodeling [62]