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A specific drug combination can also increase the risk of serious adverse effects

In recent years, Semaglutide has emerged as a game-changer in the realm of weight loss treatments

[13] These findings are further reinforced by pharmacovigilance data from the FDA Adverse Event Reporting System (FAERS) database (n=48,214 reports), where GLP-1RA-related gastrointestinal adverse events, including nausea (9651 vs 38,030) and vomiting (4383 vs 17,062), were lower with combination therapy compared to GLP-1RA monotherapy, suggesting improved tolerability when metformin is added

Retatrutide is a single-molecule triple agonist hitting the GIP, GLP-1, and glucagon receptors