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Never adjust dosing without medical guidance

When compared to Naltrexone/Bupropion combinations, the survival curves showed sustained separation throughout the observation period, with the most pronounced associations observed for oculomotor binocular dysfunction (HR 0.31, 95% CI: 0.160.60, p = 2.3 10 4 ), cataracts (HR 0.46, 95% CI: 0.230.92, p = 0.025), visual issues and blindness (HR 0.44, 95% CI: 0.260.76, p = 0.003), dry eye disease (HR 0.33, 95% CI: 0.150.71, p = 0.003), ametropic accommodative dysfunction (HR 0.31, 95% CI: 0.160.62, p = 4.3 10 4 ), and visual disturbances (HR 0.46, 95% CI: 0.260.83, p = 0.008)

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Less common symptoms include vomiting and blood in the stool