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Dr Alex Kent, medical director, NHS North East and Cumbria Integrated Care Board (ICB) said: "Weight loss medicines can work well for people who need them, but they should only be used when prescribed by a healthcare professional

PUFAs can inhibit lipogenic gene transcription by downregulating the expression SREBPs [132, 133, 134, 135] and act as antagonists of liver X receptors (LXR) [136, 137] and as agonists for PPARs [122, 123, 124, 138, 139]

Santa Catalina Monastery: A colonial architectural gem of more than 20,000 m with narrow streets, plazas, and gardens that will transport you back 400 years

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