Recently, the pharmacotherapy of MASLD mainly focuses on three parts of mechanisms: anti-inflammatory (ASK1 inhibitors), anti-diabetic (GCGR agonists, PPAR agonists), and prevention of lipotoxicity (FXR agonists, FGF21 analogues) ( FIGURE 1 Glucagon-like peptide-1 (GLP-1) is a polypeptide secreted by intestinal L cells, with its receptors widely distributed throughout the body
Qual Life Res 30(7):20332043 Alhindi Y, Avery A (2022) The efficacy and safety of oral semaglutide for glycaemic management in adults with type 2 diabetes compared to subcutaneous semaglutide, placebo, and other GLP-1 RA comparators: a systematic review and network meta-analysis
Seek emergency care if: you experience severe abdominal pain radiating to your back (possible pancreatitis), persistent vomiting that prevents hydration for more than 24 hours, signs of severe dehydration (fainting, confusion, dark concentrated urine), or if you suspect you administered five or more times your intended dose
Hair thinning or shedding may also occur with rapid weight loss