nrf2 glutathione synthesis Effect of activators on release of glutathione, cysteinylglycine and homocysteine by human U373 astroglial cells Glutathione S-transferase pi expression regulates

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A mitochondria-targeted covalent organic framework (COF) prodrug that is selectively activated by high intramitochondrial GSH levels was shown to trigger catalase collapse within the organelle, thereby amplifying local chemodynamic therapy (CDT) through enhanced ROS accumulation and mitochondrial dysfunction