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Metrics of PBMCs mitochondrial function in MASLD Mitochondria can adapt their number, mass, and activity through mitohormetic mechanisms in response to changes in energy demand and availability during the early stages of liver disease [10, 11, 64, 65]

Biosynthesis of H 2 S H 2 S can be generated in mammalian physiology via dedicated endogenous enzymatic systems, gut microbiota metabolism and the breakdown of dietary polysulphide sources such as, for example, garlic and onion (reviewed e.g