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Igarashi et al

Pre-clinical data in multiple cancer cell lines (including breast, ovarian, pancreatic, colon, non-small cell lung, prostate, thyroid, hepatocellular and oral squamous cell carcinomas and melanoma) have shown the potentiation by HDIs of the effects of topoisomerase I inhibitors (camptothecin, irinotecan, topotecan) topoisomerase II inhibitors (epirubicin, doxorubicin, etoposide, mitoxantrone) and other DNA-damaging agents (cisplatin, oxaliplatin, bleomycin)

The proposed approach can be applied in future studies to compare accessibility in urban areas and foster solutions for active and inclusive mobility

Its also best to avoid consuming it alongside milk or tea/coffee, since these can interfere with digestion and decrease uptake