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Reduced shedding appears within 2 to 4 weeks

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The SURMOUNT-4 trial (Aronne 2023, JAMA) showed that adults who stopped tirzepatide after 36 weeks regained an average of 14.0% of body weight over the next 52 weeks, while those who continued tirzepatide lost an additional 5.5% a 19.4% between-group difference