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Furthermore, safety data were collected using different methods, such as check boxes questionnaires, open format questionnaires, or verbal questioning, which may also have contributed to heterogeneity across safety outcomes

A press release issued by the American Academy of Ophthalmology stated that a recent study has found GLP-1 drugs can increase the risk of diabetic retinopathy and non-arteritic anterior ischemic optic neuropathy (NAION). The press release specifically states: Results showed that people using GLP-1 drugs were 68.6 times more likely to develop NAION and eight times more likely to develop diabetic retinopathy than those taking empagliflozin, exenatide, insulin or metformin