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The patient underwent surgical procedures over the course of several years in order to excise the giant congenital nevus from her face and to reconstruct her face using a combination of serial excision, tissue expansion, and skin grafting

The blockade of ERK1/2 activation by U0126 (a MAPK kinases inhibitor) attenuated the IRE1 level, suggesting that ERK1/2 activation causes ER stress activation in PFOS-treated RTCs (Fig