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In terms of prognosis, the 5-year event-free survival (EFS) was 84.9% (SE 3.4%) for pegaspargase and 88.1% (SE 3.0%) for calaspargase pegol

The treatment of a severe deficiency is divided into two phases: High-dose restorative therapy (injection) Through injections with B12, the bodys depleted stores are replenished and blood values quickly raised Maintenance treatment (tablets/capsules or injection) Through an oral follow-up treatment, values are stabilised and maintained

It produces strong GH pulses, with a mean peak GH increase of approximately 7-8-fold above baseline in fasting subjects at a 100 mcg intravenous dose

Each of these vulnerabilities translates directly into shorter shelf life for peptides that contain these residues