Primary care evaluation should include cardiovascular risk assessment, kidney function screening, and baseline glucose control evaluation, especially if the patient has prediabetes or diabetes
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Patients should always work closely with a board-certified physician who can evaluate their health history, monitor for risks, and tailor dosing safely
Over-interpretation of secondary outcomes may lead to spurious inferences, underscoring the need for caution when translating these findings into clinical reassurance.This aligns with emerging data linking metabolic improvements such as weight loss, insulin sensitivity, and reduced inflammation to decreased malignancy risk in high-risk populations with type 2 diabetes or obesity (Marso et al., 2016a