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Patients with a history of medullary thyroid carcinoma or MEN 2 syndrome should not use any GLP-1 receptor agonist

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44,45 In a meta-analysis of 48 RCTs including 27,729 participants, the overall incidence of GI adverse events was reported to be 11.6%, with nausea identified as the most common symptom (21.4%)

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Several factors explain why it functions as the core of most protocols

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Because of this uncertainty, Ozempic carries a boxed warning , the strongest type the FDA issues, for the potential risk of certain thyroid cancers, including medullary thyroid carcinoma

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