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However, the findings in some patient series indicate that the prevalence of iron deficiency may be even higher in the group with HFpEF.46 Some studies investigating intravenous iron administration in patients with preserved EF47,48 have also reported benefits in quality of life and functional capacity

Some chronic or severe injuries require extended protocols beyond typical 12-week durations

These findings suggest that Ti-EVs isolated by sedimentation are contaminated by membrane debris or/and other lipid particles that migrate together with Ti-EVs into the same density gradient (Hurwitz et al