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It is clear that neither X-ray crystallography nor cryo-EM can obtain a high resolution structure for intrinsically disordered proteins (IDPs) and intrinsically disordered regions (IDRs) because of a very simple reason: unlike ordered, well-folded proteins and domains, IDPs/IDRs do not adopt a single, stable three-dimensional structure

This work was supported by the Hubei Provincial Natural Science Foundation (2022CFB453), the Faculty Development Grants from Hubei University of Medicine (2018QDJZR04), Hubei Key Laboratory of Wudang Local Chinese Medicine Research (Hubei University of Medicine) (Grant No