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doi: 10.3389/fnmol.2022.1014251 63

Contrave is not appropriate for people with seizure disorders, uncontrolled high blood pressure, certain eating disorder histories, or current opioid use

GLP-1 therapy is contraindicated in patients with a personal or family history of medullary thyroid carcinoma (MTC) or Multiple Endocrine Neoplasia syndrome type 2 (MEN2)