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Activation of the FGF19 gene results in the protein being secreted into the enterohepatic circulation

The positively charged lysine side chain at physiological pH may play a role in interactions with negatively charged cellular surfaces, with extracellular matrix components, and with DNA, and may contribute to the cellular uptake and tissue distribution properties of the complex

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However, other studies have demonstrated important effects of l-carnitine on oxidative stress, as in patients with renal disease [59], phenylketonuria [60], and nonalcoholic steatohepatitis [61], as well as on several experimental models of oxidative stress [6264]