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Berberine demonstrates DPP-4 inhibitory activity in cell culture and animal studies, potentially extending the half-life of naturally produced GLP-1

Thalidomide a drug, perhaps known more for its controversial 1950s history as a sedative for pregnant women with morning sickness, which was withdrawn after it was found to lead to severe skeletal birth defects was repurposed and approved by the FDA about 60 years later for use in combination with dexamethasone in patients with newly diagnosed multiple myeloma

10.1038/nature01819 145 NogueiraN

L-Carnitine supplements boost the bodys own liver and kidney-based production of a nutrient that can benefit muscle performance, burn fat, and reduce fatigue