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Large-scale clinical trials with semaglutide (STEP 1) found that roughly 40% of total weight loss came from lean body mass (LBM), which is higher than the roughly 25% expected during typical physiological weight loss (the so-called "quarter fat-free mass rule")

This "whole-body" approach is central to how we think about supplementation

It has been hypothesized that this mechanism may involve changes in splicing inserts, similar to those at SS1 and SS6 sites in neurexin-1 [72, 96]

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