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Sleep Apnea and Musculoskeletal Outcomes The TRIUMPH-4 and TRIUMPH-5 arms target obstructive sleep apnea and knee osteoarthritis, reflecting the broader idea that substantial weight loss can improve structural and respiratory comorbidities

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therefore, when a target is inhibited or activated, the body may compensate for this change via other pathways, which may lead to diminished therapeutic efficacy or rebound of the disease, creating a rebound effect [337]