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Advantages of Injectable GLP-1 Drugs# Higher Peak Efficacy# Injectable formulations currently deliver higher peak weight loss: Best injectable: Tirzepatide at 20.9% (72 wk), retatrutide at 28.7% (68 wk) Best oral: Oral semaglutide 50 mg at 15.1% (68 wk), aleniglipron at 15.3% (36 wk, placebo-adjusted) For patients seeking maximum weight loss, injectables remain the more potent option as of early 2026