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Theoretical Concerns From Mechanism While NNMT inhibition is a promising research target, the mechanism raises points that warrant caution in interpretation

[28] Role of glutathione in skin disorders other than hyperpigmentation A decrease in the cellular and serum levels of glutathione has been speculated to be associated with the pathogenesis of autoimmune and inflammatory dermatoses that include psoriasis, vitiligo, alopecia areata, polymorphic light eruption, acne vulgaris, etc

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