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188 HSP90 as a master regulator of oncogenic signaling networks HSP90 is frequently overexpressed in cancers such as cholangiocarcinoma, lung cancer, gastric cancer, breast cancer, and glioblastoma, and its elevated levels are often associated with poor prognosis

However, during this process, some electrons can escape from the ETC and react with oxygen, forming superoxide anions (O 2 ), a type of ROS

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