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Accordingly, increased serum markers of intestinal barrier damage and epithelial apoptosis, such as intestinal fatty acid-binding protein (I-FABP), and cytokeratin 18 have been found in patients with T1D [59]

The paratope of Fab 3F52 involves residues of all complementarity determining regions (CDRs) of both heavy and light chain variable regions (VH and VL), although the CDR3 loops appear to be responsible for the most critical interactions covering a major part of the hydrophobic interface

Dalton WS, Durie BG, Alberts DS, Gerlach JH, Cress AE

Involvement of CB1 receptors in the ventral tegmental area in the potentiation of morphine rewarding properties in acquisition but not expression in the conditioned place preference model