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Our results are in line with previous reports emphasising that the available ELISA kits to quantify BDNF isoforms, especially mBDNF, need to increase their specificity to be suitable as biomarkers in biomonitoring programmes as well as in clinical applications 31,32

Reestablishing immune tolerance and immunological homeostasis are ambitious goals in the way to overcome the disease

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247 When considering whether or not to pursue assisted reproductive techniques, it is worth bearing in mind that these procedures come with known and theoretical risks