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These side effects typically occur at the start of treatment and when switching to a higher dosage but tend to improve with time

However, a retrospective cohort study published in Diabetes Care did find that use of GLP-1 medications for 1-3 years was associated with a slightly increased risk of all thyroid cancer (adjusted hazard ratio 1.58) and medullary thyroid cancer specifically (adjusted hazard ratio 1.78)

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Key Points Some people feel tired after taking tirzepatide weight loss medications (Zepbound and Mounjaro) Symptoms of fatigue tend to be temporary and improve as the body adjusts to the medication Apart from the medications direct effect, there are other reasons why tirzepatide may indirectly make you tired Feeling exhausted on tirzepatide