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One clinical trial from 2021 found that, after 68 weeks, participants with obesity who took the full dose of Ozempic and made lifestyle changes lose 14.9% of their body weight an average of 34 pounds per participant

Along this line, a recent large case-control study from 2024 including 162,253 obese patients treated with GLP-1 RAs and a matched group of untreated patients found an association between GLP-1 RAs and increased risk of depression, anxiety and suicidal behavior [10]

Cytokine Production: GLP-1R activation directly inhibits the production of pro-inflammatory cytokines (TNF-, IL-1, IL-6) and increases anti-inflammatory mediators like adiponectin

Scand J Infect Dis