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87 Thus, high GSH may reduce the mutation rate in genes encoding drug targets such as ribosomal proteins or DNA gyrase

Because ethanol metabolism by ADH and ALDH occurs essentially only in the liver, any of the adverse effects described above that are associated with ethanol metabolism by these enzymes, and the associated ROS production, primarily affect that organ

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Another study found that the gut microbiota of patients with CHE were characterized by loss of Eubacteriaceae and Sutterellaceae , including Eubacterium , Lachnospira , Parasutterella , and Erysipelotrichaceae , and enrichment of Clostridiales , including Odoribacter , Flavonifractor , and Coprobacillus [71]