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May J, Carson KR, Butler S, Liu W, Bartlett NL, Wagner-Johnston ND

Side Effects & Safety Injection site stinging/burning very common, lasting 5-15 minutes (most frequently reported side effect) Mild flushing occasional, less intense than IV route IV-specific: flushing, warmth, chest tightness, nausea common and rate-dependent, managed by slowing infusion GI discomfort with oral precursors mild and infrequent at standard doses Insomnia occasional if taken late in the day (avoid evening dosing) No serious adverse events reported in published human trials for NR 1000 mg/day or NMN 250 mg/day mg to Units Conversion On a standard 100-unit insulin syringe, each "unit" equals 0.01 mL (so 100 units = 1 mL)

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Distribution of GLP-1 binding sites in the rat brain: evidence that exendin-4 is a ligand of brain GLP-1 binding sites