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In the studies discussed below it is an umbrella term for several distinct, separately measurable events: Neurogenesis the birth of new neurons from neural progenitor cells, typically assessed with markers such as BrdU incorporation and doublecortin

& Norenberg, M

Other high-risk markers include baseline systolic BP below 115 mmHg, age over 75 (reduced hepatic clearance), concurrent use of diltiazem or verapamil (also CYP3A4 substrates and inhibitors), and renal impairment (which slows amlodipine clearance independently)

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