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We have also showed that other markers of DNA damage/cell cycle (p21, p53, p57 and phospho-p57, GADD45, 8-OHdG), apoptotic (BCL-2, CASP-2, CASP-9) and anti-oxidant pathways (GP-1, SOD-1, HO-1, p38 stress kinase), that are not specifically associated with hair follicle pigmentation, have distinct expression patterns and colocalise to parts of the hair follicle such as the IRS, ORS, DP and cortex

However, many of the changes that negatively affect how we look and feel stem from specific biological shifts that can be traced, understood, and addressedrather than simply accepted

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