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By 2030, the total number of cases of MASLD is predicted to increase by 18.3%, with the number of cases related to advanced liver disease and liver-related mortality doubling (13), posing a significant challenge to health

(2013), Guidance for industry and FDA staff

Interestingly, Ruminocaccaceae family, have been associated with the organic metabolite Trimethylamine N-oxide (TMAO) levels, playing an important role in the development of atherosclerosis and increased cardiovascular risk 127 ,while Bifidobacteriaceae or Streptococcaceae influence on glucose and fat metabolism 126

Gamma-glutamyl transferase (GGT) is a cell surface enzyme