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What Clinical Trials Reveal About Semaglutide The efficacy of semaglutide is backed by extensive clinical research, most notably the landmark STEP (Semaglutide Treatment Effect in People with Obesity) clinical trial program: Substantial Weight Reduction: Participants using therapeutic doses of semaglutide achieved an average body weight reduction of 15% to 20% over a 68-week period when paired with basic lifestyle guidance

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