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Research in mice showed retatrutide increased fatty acid oxidation in the liver and stimulated lipolysis (fat breakdown) in adipose tissue through GIP receptor activation

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The quite unexpected positive cardiorenal outcomes that have emerged from the cardiovascular outcomes trials (CVOTs) with both glucagon like peptide-1 receptors agonists (GLP-1RA) and sodium-glucose co-transporter 2 (SGLT-2) inhibitors have produced a shift of diabetes management from the meticulous glycemic control alone to the simultaneous improvement of CV outcomes